Name: LM11A-31
Brand: Selleck Chemicals
SKU: S9848
Rating: 5 (1 reviews)

LM11A-31 is a small molecule p75^NTR Ligand that reverses cholinergic neurite dystrophy in alzheimer's diseasemousemodels with mid- to late-stage disease progression.

LM11A-31 Chemical Structure

CAS: 289475-77-0

Purity & Quality Control

Batch: S984801 DMSO] 49 mg/mL] false] Water] 49 mg/mL] false] Ethanol] 49 mg/mL] false Purity: 99.49%

99.49

LM11A-31 Related Products

Biological Activity

Description	LM11A-31 is a small molecule p75^NTR Ligand that reverses cholinergic neurite dystrophy in alzheimer's diseasemousemodels with mid- to late-stage disease progression.

In vitro
In vitro	LM11A-31 greatly reduces or eliminates the neuronal pathology as well as the FIV effects on astrocytes and microglia in an infectious in vitro model, indicating an excellent potential for the treatment of HIV-associated neurodegeneration.<sup><a class="sref" href="#s_ref">[1]</a></sup>
Cell Research	Cell lines	Feline choroid plexus macrophages infected with FIV
	Concentrations	10 nM
	Incubation Time	14 h
	Method	Cat neurons were seeded at a very low density and half the cultures were treated with 10 nM LM11A-31 in the medium. Initial seeding density was matched within each run at approximately 2,800-4,000 cells/cm2 and cultures were fed every 2 days with complete MEM or MEM + LM11A-31.

In Vivo
In vivo	LM11A-31 is a small molecular p75<sup>NTR</sup> ligand, which reverses cholinergic neurite dystrophy in mice with advanced Alzheimer's disease.<sup><a class="sref" href="#s_ref">[2]</a></sup>
Animal Research	Animal Models	Thy-1 hAPP^Lond/Swe (APP^L/S) and Tg2576 mouse model
	Dosages	50 mg/kg for APP^L/S mouse; 10, 50, 75 and 100 mg/kg/day (n=3-4 Tg2576 mice/dose)
	Administration	Oral gavage

References

Chemical Information & Solubility

Molecular Weight	243.35	Formula	C₁₂H₂₅N₃O₂
CAS No.	289475-77-0	SDF	--
Smiles	CCC(C)C(N)C(=O)NCCN1CCOCC1
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 49 mg/mL ( (201.35 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 49 mg/mL

Ethanol : 49 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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% DMSO + % + % Tween 80 + % ddH₂O

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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