Home Endocrinology & Hormones GHSR inhibitor Lanreotide

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Lanreotide GHSR inhibitor

Cat.No.S6948

Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, ITM-014, Lanreotidum), an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). This compound also has antitumoral effects.

Lanreotide GHSR inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 1096.32

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Quality Control

Batch: Purity: 99.75%
99.75

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (91.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

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Mass Concentration Volume Molecular Weight
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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 1096.32 Formula

C54H69N11O10S2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 108736-35-2 -- Storage of Stock Solutions

Synonyms Laromustine, Angiopeptin, BIM 23014, BIM 23014C, BM 23014, Dermopeptin, ITM-014, ITM-014T, Lanreotidum SMILES CC(C)C1NC(=O)C(CCCCN)NC(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CSSCC(NC1=O)C(=O)NC(C(C)O)C(N)=O)NC(=O)C(N)CC5=CC6=CC=CC=C6C=C5

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
growth hormone
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-09-02)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06878664 RECRUITING
Grade1-2 Advanced Midgut Neuroendocrine Tumors (NETs)
Grupo Espanol de Tumores Neuroendocrinos
 2025-06-12 PHASE3
NCT06807437 RECRUITING
Pancreatic Carcinoma; Pancreatic Neoplasm
SWOG Cancer Research Network
 2025-05-09 PHASE3
NCT05048901 RECRUITING
Neuroendocrine Tumors,Gastroenteropancreatic
National Health Research Institutes, Taiwan
 2021-09-17 PHASE1; PHASE2
NCT03946527 ACTIVE_NOT_RECRUITING
Paraganglioma; Pheochromocytoma
Antonio Fojo
 2019-06-17 PHASE2
NCT05477576 RECRUITING
GEP-NET; Gastroenteropancreatic Neuroendocrine Tumor; Gastroenteropancreatic Neuroendocrine Tumor Disease; Neuroendocrine Tumors; Carcinoid; Carcinoid Tumor; Pancreatic NET
RayzeBio, Inc.
 2022-03-24 PHASE3
NCT05050942 ACTIVE_NOT_RECRUITING
Gastro-enteropancreatic Neuroendocrine Tumor
Camurus AB
 2021-10-22 PHASE3

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