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L-Lysine hydrochloride

Cat.No.S3953

L-Lysine hydrochloride is an essential amino acid. It is often added to animal feed used as a dietary supplement and plays a major role in calcium absorption, building muscle protein, recovering from surgery or sports injuries, and the body's production of hormones, enzymes, and antibodies.
L-Lysine hydrochloride Chemical Structure

Chemical Structure

Molecular Weight: 182.65

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S395301 Water]100 mg/mL]false]DMSO]Insoluble]false]]]false Purity: 98.56%
98.56

Chemical Information, Storage & Stability

Molecular Weight 182.65 Formula

C6H14N2O2.HCl

 Storage (From the date of receipt)
CAS No. 657-27-2 -- Storage of Stock Solutions

Synonyms N/A Smiles C(CCN)CC(C(=O)O)N.Cl

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro
L-Lysine (0.8 mmol/dl) inhibits (9.17%) binding of 5-HT to the 5-HT4 receptor, without any effect on 5-HT1A,2A,2B,2C,3 binding. L-Lysine (0.07 and 0.7 mmol/dl) blocks 5-HT-induced contractions of an isolated guinea pig ileum in vitro[1].
In vivo
Prolonged L-Lysine (Lys) treatment has anxiolytic effects in normally fed, stressed rats, and the metabolic effects of Lys were stress-specific. L-Lysine may be a partial 5-HT4 receptor antagonist and suppresses 5-HT4 receptor-mediated intestinal pathologies and anxiety in rats[1].
References

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