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L-carnosine

Cat.No.S5226

L-Carnosine is a dipeptide composed of beta-alanine and histidine. It is an endogenous metabolite found in all vertebrates and is present in human brain, muscle, and gastrointestinal tissues. L-Carnosine acts as a non-enzymatic free radical scavenger and a natural antioxidant. It possesses anti-inflammatory and neuroprotective properties and can inhibit biochemical changes associated with aging. In vitro studies indicate that L-Carnosine possesses antioxidant properties, primarily mediated through metal ion chelation, superoxide dismutase (SOD)-like activity, and scavenging of reactive oxygen species (ROS) and free radicals.
L-carnosine Chemical Structure

Chemical Structure

Molecular Weight: 226.23

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Quality Control

Batch: S522601 Water]45 mg/mL]false]DMSO]Insoluble]false]]]false Purity: 99.95%
99.95

Solubility

In vitro
Batch:

Water : 45 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 226.23 Formula

C9H14N4O3

 Storage (From the date of receipt)
CAS No. 305-84-0 Download SDF Storage of Stock Solutions

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05860088 Recruiting
Muscle Weakness|Muscle; Fatigue Heart|Older Adults
Indiana University
 July 10 2023 Not Applicable
NCT05371145 Recruiting
Peripheral Arterial Disease
University of Louisville
 March 1 2023 Phase 1|Phase 2
NCT04949607 Completed
Brain Injury Chronic|Brain Injuries Traumatic
Centre for Neuro Skills|University of Texas
 July 28 2021 Not Applicable

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