JX06

Catalog No.S0983

For research use only.

JX06 as a selective covalent inhibitor of PDK1 in cells. JX06 dose-dependently inhibits PDK1, PDK2 and PDK3 with IC50 0.049 μM, 0.101 μM and 0.313 μM, respectively.

JX06 Chemical Structure

CAS No. 729-46-4

Selleck's JX06 has been cited by 1 Publication

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Biological Activity

Description JX06 as a selective covalent inhibitor of PDK1 in cells. JX06 dose-dependently inhibits PDK1, PDK2 and PDK3 with IC50 0.049 μM, 0.101 μM and 0.313 μM, respectively.
Targets
PDK1 [1]
(Cell-free assay)
PDK2 [1]
(Cell-free assay)
PDK3 [1]
(Cell-free assay)
0.049 μM 0.101 μM 0.313 μM
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Kelly M1nBcWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkLpO|IhcHK| MkK0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNZXzsfUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OD1yLkK4Pe69VS5? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ|MEm4PUc,Ojh{M{C5PFk9N2F-
A549 MlvxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoLwO|IhcHK| M3jY[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygTWM2OD1yLkS4{txONg>? NID6TGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKzNFk5QSd-MkiyN|A6QDl:L3G+
A549 NGj2O2JCdnSrdIXtc5Ih[WO2aY\peJkh[XO|YYm= M1rYUlQxKHSxIEiwJI1oN2up NFS4OmozOSCmYYnz MoLWRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczD4[Y5w\3KjZoTl[EBqdiCEQVzCM4MhdnWmZTDtc5V{\SCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfHWvb4Kge4Vq\2i2IHH0JFQxKHSxIEiwJI1oN2upLDDpdEBnd3JiMkGg[IF6eyCvZXHzeZJm\CCxbjDkZZkhOjFicH;zeEBld3On M3z2bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkOwPVg6Lz5{OEKzNFk5QTxxYU6=

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 65 mg/mL
(200.3 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 324.51
Formula

C10H16N2O2S4

CAS No. 729-46-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1COCCN1C(=S)SSC(=S)N2CCOCC2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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