Home Protein Tyrosine Kinase PDGFR inhibitor JNJ-10198409 For research use only.

JNJ-10198409

JNJ-10198409, a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor with IC50 of 2 nM, is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent, has good activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.

JNJ-10198409 Chemical Structure

JNJ-10198409 Chemical Structure

CAS: 627518-40-5

Purity & Quality Control

Batch: E239301 DMSO] 65 mg/mL] false] Ethanol] 33 mg/mL] false] Water] Insoluble] false Purity: 98.89%
98.89

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Biological Activity

Description JNJ-10198409, a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor with IC50 of 2 nM, is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent, has good activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.
Targets
PDGFRβ [2]
(in an assay of the PDGF receptor kinase activity)		 PDGFRα [2]
(in an assay of the PDGF receptor kinase activity)
4.2 nM 45 nM

Chemical Information & Solubility

Molecular Weight 325.34 Formula

C18H16FN3O2
CAS No. 627518-40-5 SDF --
Smiles COC1=CC2=C(C=C1OC)C3=C(C2)C(=N[NH]3)NC4=CC=CC(=C4)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 65 mg/mL ( (199.79 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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