JNJ-10198409

Catalog No.E2393

For research use only.

JNJ-10198409, a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor with IC50 of 2 nM, is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent, has good activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.

JNJ-10198409 Chemical Structure

CAS No. 627518-40-5

Purity & Quality Control

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Biological Activity

Description JNJ-10198409, a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor with IC50 of 2 nM, is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent, has good activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.
Targets
PDGFRβ [2]
(in an assay of the PDGF receptor kinase activity)
PDGFRα [2]
(in an assay of the PDGF receptor kinase activity)
4.2 nM 45 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 325.34
Formula

C18H16FN3O2

CAS No. 627518-40-5
Storage 3 years -20°C powder
2 years -80°C in solvent

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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