Isosorbide Mononitrate

Catalog No.S4633 Synonyms: Isosorbide-5-mononitrate, Elantan, Monoket, Mononit, Imdur, Corangin

For research use only.

Isosorbide mononitrate (Elantan, Monoket, Mononit, Imdur, Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.

Isosorbide Mononitrate Chemical Structure

CAS No. 16051-77-7

Purity & Quality Control

Related Other Products

Biological Activity

Description Isosorbide mononitrate (Elantan, Monoket, Mononit, Imdur, Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 38 mg/mL
(198.8 mM)
Water 38 mg/mL
(198.8 mM)
Ethanol 38 mg/mL
(198.8 mM)

Chemical Information

Molecular Weight 191.14
Formula

C6H9NO6

CAS No. 16051-77-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02053493 Completed Drug: Isosorbide Mononitrate|Drug: Placebo Heart Failure Adrian Hernandez|National Heart Lung and Blood Institute (NHLBI)|Mayo Clinic|University of Vermont|Duke University April 2014 Phase 2
NCT02712125 Completed Drug: isosorbide mononitrate|Drug: Placebo Isolated (Idiopathic) Oligohydramnios Benha University August 2013 Phase 2|Phase 3
NCT00930618 Completed Drug: IMN|Drug: Placebo Prolonged Pregnancy|Nulliparity Assistance Publique - Hôpitaux de Paris June 2009 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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