research use only

Isopropyl myristate

Name: Isopropyl myristate
Brand: Selleck Chemicals
SKU: S2428
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S2428

Isopropyl myristate (IPM) is used as a substitute for natural oils in cosmetics and a co-solvent with skin penetration enhancement properties of active ingredients in many topical and transdermal preparations. It affects the lamellar lipid assembly in terms of bilayer perturbation and disordering.

Chemical Structure

Molecular Weight: 270.45

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S242801 Purity: 99%

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Chemical Information, Storage & Stability

Molecular Weight	270.45	Formula	C₁₇H₃₄O₂	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	110-27-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	IPM			Smiles	CCCCCCCCCCCCCC(=O)OC(C)C

Solubility

In vitro
Batch:

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References	https://pubmed.ncbi.nlm.nih.gov/28352582/ https://pubmed.ncbi.nlm.nih.gov/17942025/ https://karger.com/spp/article-abstract/25/4/200/295686/Study-of-the-Influence-of-the-Penetration-Enhancer?redirectedFrom=fulltext

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05981066	Recruiting	Advanced Hepatocellular Carcinoma	Peking Union Medical College Hospital	July 10 2023	Not Applicable
NCT03319927	Recruiting	Children Only\|Risk Reduction\|Environmental Exposure	University of California San Francisco\|National Institute of Environmental Health Sciences (NIEHS)\|University of California Berkeley\|Oregon State University	October 9 2017	Not Applicable
NCT02020226	Unknown status	Solid Tumors	Threshold Pharmaceuticals	November 2013	Phase 1
NCT01833546	Completed	Solid Tumor\|Pancreatic Cancer	Merck KGaA Darmstadt Germany\|Threshold Pharmaceuticals	April 18 2013	Phase 1

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