Iron sucrose

Catalog No.S3729 Synonyms: Iron saccharate, Sucroferric oxyhydroxide

For research use only.

Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.

Iron sucrose Chemical Structure

CAS No. 8047-67-4

Purity & Quality Control

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Biological Activity

Description Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.
In vitro

Iron sucrose (0.01 mg/mL) used as an additive to culture medium for 24 h was cytotoxic to human peritoneal mesothelial cells in in vitro culture as reflected by its effect on the cells' growth, viability and synthesis of IL-6; all these effects were dosedependent. At higher, concentrations cytotoxic effects of iron sucrose appeared. Toxic effect of iron towards the mesothelial cells may be linked to increased production of free radicals. Iron sucrose enters into the cytosol of the mesothelial cells, where it is probably transported in a process of endocytosis[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: human peritoneal mesothelial cells.
  • Concentrations: 0.01 mg/mL
  • Incubation Time: 24 h
  • Method:

    --

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(135.85 mM)
Water 100 mg/mL
(135.85 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 736.06
Formula

C18H24Fe2O24

CAS No. 8047-67-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.[Fe+3].[Fe+3]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04304625 Recruiting Drug: Tranexamic Acid / Sodium chloride Postpartum Hemorrhage University Hospital Bordeaux August 7 2020 Phase 3
NCT03917394 Unknown status Drug: rHuEPO|Drug: Iron sucrose Anemia Iron Deficiency Peking Union Medical College Hospital April 24 2019 --
NCT01438372 Withdrawn Drug: Intravenous iron sucrose|Drug: Oral ferrous sulfate Iron Deficiency Anemia|Inflammatory Bowel Disease Wayne State University|Children''s Hospital of Michigan|American Regent Inc. November 2011 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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