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Iron sucrose

Cat.No.S3729

Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.
Iron sucrose Chemical Structure

Chemical Structure

Molecular Weight: 736.06

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Chemical Information, Storage & Stability

Molecular Weight 736.06 Formula

C18H24Fe2O24

 Storage (From the date of receipt)
CAS No. 8047-67-4 Download SDF Storage of Stock Solutions

Synonyms Iron saccharate, Sucroferric oxyhydroxide Smiles C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.[Fe+3].[Fe+3]

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vitro
Iron sucrose (0.01 mg/mL) used as an additive to culture medium for 24 h was cytotoxic to human peritoneal mesothelial cells in in vitro culture as reflected by its effect on the cells' growth, viability and synthesis of IL-6; all these effects were dosedependent. At higher, concentrations cytotoxic effects of this compound appeared. Toxic effect of this chemical towards the mesothelial cells may be linked to increased production of free radicals. It enters into the cytosol of the mesothelial cells, where it is probably transported in a process of endocytosis[1].
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05921968 Not yet recruiting
Iron Deficiency Anemia
Ain Shams University
 July 30 2023 Phase 4
NCT04304625 Recruiting
Postpartum Hemorrhage
University Hospital Bordeaux
 August 7 2020 Phase 3
NCT03917394 Unknown status
Anemia Iron Deficiency
Peking Union Medical College Hospital
 April 24 2019 --

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