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Iopromide

Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of this compound, permitting radiographic visualization of the internal structures until significant hemodilution occurs.

Iopromide Chemical Structure

Chemical Structure

Molecular Weight: 791.11

Purity & Quality Control

Batch: S320701 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 99.99%
99.99

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Mechanism of Action

In vitro
In vitro No toxic effects are detected at the highest tested concentration of Iopromide (10 g/L) in short-term toxicity tests with bacteria (Vibrio fisheri, Pseudomonas putida), algae (Scenedesmus subspicatus), crustaceans (Daphnia magna), and fish (Danio rerio, Leuciscus idus). This compound results in the ratio between the predicted environmental concentration (PEC) and the predicted no-effect concentration (PNEC) of 2 × 10-4 using an assessment factor of 100. [1] It results in the photocatalytic degradation values k of 0.18 and the coefficient of determination R2 of 0.997 in Milli-Q water with suspended TiO2. [2] The percent removal of this chemical decreases from 97% to 86% when the activity of the nitrifying bacteria is inhibited. This compound results in metabolite of carboxylate formed during the oxidation of the primary alcohol on the side chain of iopromide when the nitrifying bacteria are inhibited. [3] It (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). This chemical (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). The percent removal of it in the wastewater treatment plants reaches 61% in nitrifying activated sludge. [4] This compound-dosed plant at 0.1 mg/L, 1 mg/L and 100 mg/L results in the median of DOC-degradation of the synthetic sewage of 88.5%, 90.5%, 88.4% and 85.1%, respectively. It is eliminated to more than 80% in the 100 mg/L concentration after a lag period of 31 days. In the LSTP incubated with 1 mg/L this chemical elimination reaches more than 80% after 38 days. It results in half-life of photodegradation of free amine of 4.21 hours. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
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Contrast Enhanced X-ray Based Examination
Bayer
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NCT03622801 Completed
Contrast Medium
Bayer
 October 12 2018 --
NCT01580046 Unknown status
Kidney Failure Chronic
Yong Huo|Peking University First Hospital
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References
  • https://pubmed.ncbi.nlm.nih.gov/10090816/
  • https://pubmed.ncbi.nlm.nih.gov/14769415/
  • https://pubmed.ncbi.nlm.nih.gov/4014629/
  • https://pubmed.ncbi.nlm.nih.gov/17180990/
  • https://pubmed.ncbi.nlm.nih.gov/11766804/

Chemical Information

Molecular Weight 791.11 Formula

C18H24I3N3O8
CAS No. 73334-07-3 SDF Download SDF
Synonyms N/A
Smiles CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)NC(=O)COC)I

Storage and Stability

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (126.4 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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