Iopromide

Catalog No.S3207 Batch:S320701

Technical Data

Formula	C₁₈H₂₄I₃N₃O₈
Molecular Weight	791.11	CAS No.	73334-07-3
Solubility (25°C)*	In vitro	DMSO	100 mg/mL (126.4 mM)
		Water	100 mg/mL (126.4 mM)
		Ethanol	100 mg/mL (126.4 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.
In vitro	No toxic effects are detected at the highest tested concentration of Iopromide (10 g/L) in short-term toxicity tests with bacteria (Vibrio fisheri, Pseudomonas putida), algae (Scenedesmus subspicatus), crustaceans (Daphnia magna), and fish (Danio rerio, Leuciscus idus). Iopromide results in the ratio between the predicted environmental concentration (PEC) and the predicted no-effect concentration (PNEC) of 2 × 10^-4 using an assessment factor of 100. ^[1] Iopromide results in the photocatalytic degradation values k of 0.18 and the coefficient of determination R² of 0.997 in Milli-Q water with suspended TiO₂. ^[2] The percent removal of Iopromide decreases from 97% to 86% when the activity of the nitrifying bacteria is inhibited. Iopromide results in metabolite of carboxylate formed during the oxidation of the primary alcohol on the side chain of iopromide when the nitrifying bacteria are inhibited. ^[3] Iopromide (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). Iopromide (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). The percent removal of Iopromide in the wastewater treatment plants reaches 61% in nitrifying activated sludge. ^[4] Iopromide-dosed plant at 0.1 mg/L, 1 mg/L and 100 mg/L results in the median of DOC-degradation of the synthetic sewage of 88.5%, 90.5%, 88.4% and 85.1%, respectively. Iopromide is eliminated to more than 80% in the 100 mg/L concentration after a lag period of 31 days. In the LSTP incubated with 1 mg/L Iopromide elimination reaches more than 80% after 38 days. Iopromide results in half-life of photodegradation of free amine of 4.21 hours. ^[5]

Description

Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.

In vitro

No toxic effects are detected at the highest tested concentration of Iopromide (10 g/L) in short-term toxicity tests with bacteria (Vibrio fisheri, Pseudomonas putida), algae (Scenedesmus subspicatus), crustaceans (Daphnia magna), and fish (Danio rerio, Leuciscus idus). Iopromide results in the ratio between the predicted environmental concentration (PEC) and the predicted no-effect concentration (PNEC) of 2 × 10^-4 using an assessment factor of 100. ^[1] Iopromide results in the photocatalytic degradation values k of 0.18 and the coefficient of determination R² of 0.997 in Milli-Q water with suspended TiO₂. ^[2] The percent removal of Iopromide decreases from 97% to 86% when the activity of the nitrifying bacteria is inhibited. Iopromide results in metabolite of carboxylate formed during the oxidation of the primary alcohol on the side chain of iopromide when the nitrifying bacteria are inhibited. ^[3] Iopromide (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). Iopromide (0.1 mg/L to 0.27 mg/L) is removed more effectively in the nitrifying activate sludge which has a higher SRT (49 days) than in the conventional activated sludge (SRT of 6 days). The percent removal of Iopromide in the wastewater treatment plants reaches 61% in nitrifying activated sludge. ^[4] Iopromide-dosed plant at 0.1 mg/L, 1 mg/L and 100 mg/L results in the median of DOC-degradation of the synthetic sewage of 88.5%, 90.5%, 88.4% and 85.1%, respectively. Iopromide is eliminated to more than 80% in the 100 mg/L concentration after a lag period of 31 days. In the LSTP incubated with 1 mg/L Iopromide elimination reaches more than 80% after 38 days. Iopromide results in half-life of photodegradation of free amine of 4.21 hours. ^[5]

Protocol (from reference)

References

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Selleck's Iopromide has been cited by 1 publication

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. [ Nat Commun, 2019, 10(1):2130]	PubMed: 31086178

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. [ Nat Commun, 2019, 10(1):2130]

PubMed: 31086178

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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