CAS No. 2803470-63-3
Batch:
Purity:99.38
Chemical Structure
Check the
HC-7366
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-[3-[(5-chloro-2-methoxy-3-pyridinyl)sulfonylamino]-2,6-difluorophenyl]-N-methylimidazo[1,5-a]pyrazine-1-carboxamide | |
|---|---|---|
| CAS Number | 2803470-63-3 | |
| Molecular Formula |
C20H15ClF2N6O4S |
|
| Molecular Weight (MW) | 508.89 | |
| InChIKey | KIGXQRBUVDDSPP-UHFFFAOYSA-N |
Biological Activity
HC-7366 is an orally bioavailable small-molecule activator of general control nonderepressible 2 (GCN2) kinase that exhibits selectivity over protein kinase RNA-like endoplasmic reticulum kinase (PERK). Activation of GCN2 triggers downstream integrated stress response signaling, leading to translational regulation and metabolic stress responses. Preclinical evaluation demonstrates robust cellular permeability and in vivo exposure, driving broad tumor growth inhibition and anti-metastatic activity in xenograft models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(196.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.