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Garcinol Histone Acetyltransferase inhibitor

Name: Garcinol
Brand: Selleck Chemicals
SKU: S7151
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S7151

Garcinol is a polyisoprenylated benzophenone compound isolated from the fruit rind of Garcinia indica. It acts as a potent natural inhibitor of histone acetyltransferases (HATs), including p300 and PCAF, with IC50 of ~7 μM and 5 μM, respectively. It also exhibits anti-cholinesterase activity against AChE and BChE with an IC50 of 0.66 μM and 7.39 μM, respectively.

Chemical Structure

Molecular Weight: 602.80

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Quality Control

Batch: S715101 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.91%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.91

Related Targets	HDAC JAK BET Histone Methyltransferase PKC PARP HIF PRMT EZH2 AMPK
Other Histone Acetyltransferase Inhibitors	PF-9363 (CTx-648) C646 MG149 Remodelin Hydrobromide WM-1119 YF-2 JQAD1 EML 425 CPTH2 WM-3835

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (165.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	602.80	Formula	C₃₈H₅₀O₆	Storage (From the date of receipt)	2 years -80 in solvent
CAS No.	78824-30-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/17960072/ [2] https://pubmed.ncbi.nlm.nih.gov/15155757/

Tech Support

Handling Instructions

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