CAS No. 78824-30-3
Batch:
Purity:99.91
Chemical Structure
Check the
Garcinol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,3Z,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxymethylidene]-6,6-dimethyl-5,7-bis(3-methylbut-2-enyl)-1-[(2S)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione | |
|---|---|---|
| CAS Number | 78824-30-3 | |
| Molecular Formula |
C38H50O6 |
|
| Molecular Weight (MW) | 602.80 | |
| InChIKey | DTTONLKLWRTCAB-BZSUNBQASA-N |
Garcinol is a polyisoprenylated benzophenone natural compound that acts as an inhibitor of histone acetyltransferases (HATs), specifically p300 (IC50 ~7 μM) and PCAF (IC50 5 μM). Inhibition of HAT activity by garcinol blocks histone acetylation and chromatin transcription. Downstream, garcinol modulates key signaling pathways, inducing apoptosis, suppressing NF-kB activation, and inhibiting cancer cell proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(165.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.