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Gadobutrol

Cat.No.S3497

Gadobutrol (Gadovist, Gadavist,ZK 135079) is a non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is usedfor tissue contrast enhancement in magnetic resonance imaging (MRI).
Gadobutrol Chemical Structure

Chemical Structure

Molecular Weight: 604.71

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Quality Control

Batch: S349701 Water]100 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99%
99

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 604.71 Formula

C18H31GdN4O9

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 138071-82-6 -- Storage of Stock Solutions

Synonyms Gadovist, Gadavist,ZK 135079 SMILES [Gd+3].OCC(O)C(CO)N1CCN(CCN(CCN(CC1)CC([O-])=O)CC([O-])=O)CC([O-])=O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-01-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04373564 RECRUITING
Motor Function; Cognitive Function; Contrast Media
Guerbet
 2021-03-24 PHASE4
NCT02156739 ACTIVE_NOT_RECRUITING
Hepatocellular Carcinoma; Liver and Intrahepatic Bile Duct Disorder; Metastatic Malignant Neoplasm in the Liver; Primary Malignant Liver Neoplasm
M.D. Anderson Cancer Center
 2014-10-13
NCT07796360 NOT_YET_RECRUITING
Healthy Volunteers
National Institute of Neurological Disorders and Stroke (NINDS)
 2026-09-14 PHASE1
NCT04369560 RECRUITING
Urinary Bladder Neoplasms
Jodi Maranchie
 2025-05-23 EARLY_PHASE1
NCT07472491 RECRUITING
Known or Highly Suspected Central Nervous System (CNS) Lesion; Known or Highly Suspected Body (Excluding CNS) Lesion
GE Healthcare
 2026-04-01 PHASE2; PHASE3
NCT04219904 ACTIVE_NOT_RECRUITING
Stage IA Cervical Cancer; Stage IA1 Cervical Cancer; Stage IA2 Cervical Cancer; Stage IB Cervical Cancer; Stage IB1 Cervical Cancer; Stage IB2 Cervical Cancer; Stage IB3 Cervical Cancer
M.D. Anderson Cancer Center
 2018-09-07 EARLY_PHASE1

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