G-1

Catalog No.S0851 Synonyms: LNS 8801

For research use only.

G-1 (LNS 8801) is a nonsteroidal and selective agonist of G protein-coupled receptor 30 (GPR30, G protein-coupled estrogen receptor 1, GPER) with Ki of 11 nM.

G-1 Chemical Structure

CAS No. 881639-98-1

Purity & Quality Control

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Biological Activity

Description G-1 (LNS 8801) is a nonsteroidal and selective agonist of G protein-coupled receptor 30 (GPR30, G protein-coupled estrogen receptor 1, GPER) with Ki of 11 nM.
Targets
GPR30 [1]
(Cell-free assay)
11 nM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 412.28
Formula

C21H18BrNO3

CAS No. 881639-98-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)C1=CC2=C(C=C1)NC(C3C2C=CC3)C4=CC5=C(C=C4Br)OCO5

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04477291 Recruiting Drug: CG-806 Acute Myeloid Leukemia|Myelodysplastic Syndromes Aptose Biosciences Inc. October 6 2020 Phase 1
NCT04286152 Unknown status Drug: Mirabegron 50 MG|Drug: Placebo oral tablet Nephrolithiasis Unity Health Toronto|Canadian Urological Association February 3 2020 Phase 3
NCT04040712 Completed Other: Donor FMT|Other: Sham FMT Diarrhea Caused by Drug (Disorder)|Renal Cell Cancer Catholic University of the Sacred Heart August 2 2019 Not Applicable
NCT03893682 Recruiting Drug: CG-806 Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Non-Hodgkin''s Lymphoma Aptose Biosciences Inc. April 30 2019 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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