Furamidine dihydrochloride

Catalog No.E7603 Batch:E760301

Technical Data

Formula

C₁₈H₁₆N₄O.2ClH

Molecular Weight

377.27

CAS No.

55368-40-6

Solubility (25°C)*

In vitro

Water

9 mg/mL (23.85 mM)

DMSO

6 mg/mL (15.9 mM)

Ethanol

Insoluble

In vivo (Add solvents to the product individually and in order)

Clear solution	saline	9.000mg/ml (23.86mM)	Taking the 1 mL working solution as an example, add 9 mg of this product to 1 ml of physiological saline (0.9% NaCL solution), mix evenly to make it clear, The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Furamidine dihydrochloride (DB75 dihydrochloride, NSC 305831 dihydrochloride) is a potent and selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of 9.4 μM. It is also a potent inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1). It exhibits potent anti-Plasmodium vivax and antiparasitic activity in vitro and in vivo, and its ability to disrupt mitochondrial membranes also supports its use as an antimicrobial agent.

Description

Furamidine dihydrochloride (DB75 dihydrochloride, NSC 305831 dihydrochloride) is a potent and selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of 9.4 μM. It is also a potent inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1). It exhibits potent anti-Plasmodium vivax and antiparasitic activity in vitro and in vivo, and its ability to disrupt mitochondrial membranes also supports its use as an antimicrobial agent.

Protocol (from reference)

References

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.