CAS No. 55368-40-6
Batch:
Purity:98.18
Chemical Structure
Check the
Furamidine dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide;dihydrochloride | |
|---|---|---|
| CAS Number | 55368-40-6 | |
| Molecular Formula |
C18H16N4O.2ClH |
|
| Molecular Weight (MW) | 377.27 | |
| InChIKey | VXNYQUQHOUERTR-UHFFFAOYSA-N |
Furamidine dihydrochloride is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) and tyrosyl-DNA phosphodiesterase 1 (Tdp1). As a DNA minor groove-binding agent, it disrupts mitochondrial membrane integrity and inhibits nucleic acid synthesis, impairing cellular proliferation and gene expression. Consequently, this compound exhibits potent antimicrobial and antiparasitic activities in vitro and in vivo, notably against protozoan pathogens including Plasmodium species. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 9 mg/mL |
| DMSO |
6 mg/mL
(15.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.