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Eperisone hydrochloride

Cat.No.S4877

Eperisone hydrochloride is muscle relaxant agent with antispasmodic effects. It is widely used in the treatment of patients with muscular contractures, low back pain or spasticity.
Eperisone hydrochloride Chemical Structure

Chemical Structure

Molecular Weight: 295.85

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Quality Control

Batch: S487701 DMSO]59 mg/mL]false]]]false]]]false Purity: 99.86%
99.86

Solubility

In vitro
Batch:

DMSO : 59 mg/mL (199.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 295.85 Formula

C17H25NO.HCl

 Storage (From the date of receipt)
CAS No. 56839-43-1 -- Storage of Stock Solutions

Synonyms N/A Smiles CCC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2.Cl

Mechanism of Action

In vivo
Eperisone has very low bioavailability after oral administration in rats and extensively high oral clearance in humans. It undergoes extensive first-pass metabolism after oral administration in rats and humans because absorption of the drug is very high. The bioavailabilities in the intestine were 0.176 and 0.0879 at administration rates of 100 and 25 mg/h/kg, respectively, whereas those in the liver were 0.532 and 0.486, respectively. Eperisone has high metabolic clearance in the small intestine.
References

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