Eperisone hydrochloride

Eperisone hydrochloride is muscle relaxant agent with antispasmodic effects. It is widely used in the treatment of patients with muscular contractures, low back pain or spasticity.

Eperisone hydrochloride Chemical Structure

Eperisone hydrochloride Chemical Structure

CAS: 56839-43-1

Purity & Quality Control

Batch: S487701 DMSO] 59 mg/mL] false] ] ] false] ] ] false Purity: 99.86%
99.86

Eperisone hydrochloride Related Products

Biological Activity

Description Eperisone hydrochloride is muscle relaxant agent with antispasmodic effects. It is widely used in the treatment of patients with muscular contractures, low back pain or spasticity.
In Vivo
In vivo Eperisone has very low bioavailability after oral administration in rats and extensively high oral clearance in humans. It undergoes extensive first-pass metabolism after oral administration in rats and humans because absorption of the drug is very high. The bioavailabilities in the intestine were 0.176 and 0.0879 at administration rates of 100 and 25 mg/h/kg, respectively, whereas those in the liver were 0.532 and 0.486, respectively. Eperisone has high metabolic clearance in the small intestine[1].
Animal Research Animal Models Male Wistar rats
Dosages 25 mg/h/kg
Administration infused from the femoral vein, portal vein and duodenum

Chemical Information & Solubility

Molecular Weight 295.85 Formula

C17H25NO.HCl

CAS No. 56839-43-1 SDF --
Smiles CCC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 59 mg/mL ( (199.42 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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