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DSPE-PEG 2000

DSPE-PEG 2000 is a lipid-polymer conjugate used to form stable micelles for drug delivery, with the PEG head group enhancing biocompatibility and circulation time. The micelles undergo a phase transition at 12°C, from a glassy to a fluid phase, affecting stability and monomer desorption rates. The size of the PEG chain and lipid tail influence the micelles transition temperature and overall behavior in drug delivery systems.

DSPE-PEG 2000 Chemical Structure

DSPE-PEG 2000 Chemical Structure

CAS No. 892144-24-0

Purity & Quality Control

DSPE-PEG 2000 Related Products

Biological Activity

Description DSPE-PEG 2000 is a lipid-polymer conjugate used to form stable micelles for drug delivery, with the PEG head group enhancing biocompatibility and circulation time. The micelles undergo a phase transition at 12°C, from a glassy to a fluid phase, affecting stability and monomer desorption rates. The size of the PEG chain and lipid tail influence the micelles transition temperature and overall behavior in drug delivery systems.
  • https://pubmed.ncbi.nlm.nih.gov/19358585/

Chemical Information & Solubility

Molecular Weight Formula

(C2H4O)nC42H82NO10P
CAS No. 892144-24-0 SDF Download DSPE-PEG 2000 SDF
Storage (From the date of receipt)

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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