Home Angiogenesis Src inhibitor DGY-06-116

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DGY-06-116 Src inhibitor

Cat.No.S9643

DGY-06-116 is an irreversible covalent and selective inhibitor of Src with IC50 of 2.6 nM.
DGY-06-116 Src inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 597.11

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S964301 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.86%
99.86

Chemical Information, Storage & Stability

Molecular Weight 597.11 Formula

C32H33ClN8O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2556836-50-9 -- Storage of Stock Solutions

Synonyms N/A Smiles CN1CCN(CC1)C2=CC=C(NC3=NC(=C(C=N3)C(=O)NC4=C(Cl)C=CC=C4C)NC5=CC=CC=C5NC(=O)C=C)C=C2

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (167.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Src [1]
(Cell-free assay)
2.6 nM
In vitro

DGY-06-116 inhibits Src enzymatic activity. This compound binds covalently to Src in a manner similar to SM1-71, where the p-loop must kink to establish the covalent bond.[1]
References

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