DGY-06-116

Catalog No.S9643

For research use only.

DGY-06-116 is an irreversible covalent and selective inhibitor of Src with IC50 of 2.6 nM.

DGY-06-116 Chemical Structure

CAS No. 2556836-50-9

Purity & Quality Control

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Biological Activity

Description DGY-06-116 is an irreversible covalent and selective inhibitor of Src with IC50 of 2.6 nM.
Targets
Src [1]
(Cell-free assay)
2.6 nM
In vitro

DGY-06-116 inhibits Src enzymatic activity. DGY-06-116 binds covalently to Src in a manner similar to SM1-71, where the p-loop must kink to establish the covalent bond.[1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 597.11
Formula

C32H33ClN8O2

CAS No. 2556836-50-9
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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