CAS No. 960539-70-2

Batch: Purity:99.80
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Daprodustat (GSK1278863) Chemical Structure
Chemical Structure
Check the Daprodustat (GSK1278863) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid
CAS Number 960539-70-2
Molecular Formula

C19H27N3O6
Molecular Weight (MW) 393.43
SMILES C1CCC(CC1)N2C(=O)C(C(=O)N(C2=O)C3CCCCC3)C(=O)NCC(=O)O
InChIKey RUEYEZADQJCKGV-UHFFFAOYSA-N

Ordering Information

Biological Activity

Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. By inhibiting HIF-PH enzymes, it prevents the proline hydroxylation and subsequent ubiquitin-proteasomal degradation of hypoxia-inducible factor alpha (HIF-α) subunits. This leads to the stabilization and nuclear accumulation of HIF-1α and HIF-2α, activating transcription of target genes in the HIF signaling pathway that induce erythropoietin expression and promote erythropoiesis. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 4 mg/mL (10.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.