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Dansylcadaverine (Monodansyl cadaverine)

Cat.No.E0451

Dansylcadaverine (Monodansyl cadaverine, MDC) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands.

Dansylcadaverine (Monodansyl cadaverine) Chemical Structure

Chemical Structure

Molecular Weight: 335.46

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Quality Control

Batch: E045101 DMSO]67 mg/mL]false]Ethanol]8 mg/mL]false]Water]Insoluble]false Purity: 98.95%
98.95

Solubility

In vitro
Batch:

DMSO : 67 mg/mL (199.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 335.46 Formula

C17H25N3O2S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 10121-91-2 -- Storage of Stock Solutions

Synonyms MDC, Monodansyl cadaverine Smiles CN(C)C1=CC=CC2=C(C=CC=C12)[S](=O)(=O)NCCCCCN

Mechanism of Action

In vitro

Dansylcadaverine is an autofluorescent compound used for the labeling of autophagic vacuoles, which is able to serve as a substrate for transglutaminases and to block competitively the crosslinking of fibrin molecules.
References

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