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Dansylcadaverine (Monodansyl cadaverine)

Synonyms: MDC, Monodansyl cadaverine

Dansylcadaverine (Monodansyl cadaverine, MDC) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands.

Dansylcadaverine (Monodansyl cadaverine) Chemical Structure

Dansylcadaverine (Monodansyl cadaverine) Chemical Structure

CAS: 10121-91-2

Purity & Quality Control

Batch: E045101 DMSO] 67 mg/mL] false] Ethanol] 8 mg/mL] false] Water] Insoluble] false Purity: 98.95%
98.95

Dansylcadaverine (Monodansyl cadaverine) Related Products

Biological Activity

Description

Dansylcadaverine (Monodansyl cadaverine, MDC) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands.
In vitro
In vitro

Dansylcadaverine is an autofluorescent compound used for the labeling of autophagic vacuoles, which is able to serve as a substrate for transglutaminases and to block competitively the crosslinking of fibrin molecules.[3]
Cell Research Cell lines MCF7 cells
Concentrations 50 mM
Incubation Time 15 min
Method

MCF7 cells (2.4 ×104 ) are seeded into 35 mm plates. After 24 h incubation, CuO NPs are added with an increasing concentration in the presence or absence of 3-MA for different time periods. The cells are then incubated with 50 mM monodansylcadaverine at 37℃ for 15 min and washed with 1×PBS three times with 5 min interval. Finally, the cells are observed under a fluorescence microscope.

Chemical Information & Solubility

Molecular Weight 335.46 Formula

C17H25N3O2S
CAS No. 10121-91-2 SDF --
Smiles CN(C)C1=CC=CC2=C(C=CC=C12)[S](=O)(=O)NCCCCCN
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 67 mg/mL ( (199.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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