CAS No. 189232-42-6

Batch: Purity:99.04
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Bohemine Chemical Structure
Chemical Structure
Check the Bohemine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]propan-1-ol
CAS Number 189232-42-6
Molecular Formula

C18H24N6O
Molecular Weight (MW) 340.42
SMILES CC(C)N1C=NC2=C(N=C(N=C21)NCCCO)NCC3=CC=CC=C3
InChIKey OPQGFIAVPSXOBO-UHFFFAOYSA-N

Biological Activity

Bohemine is a synthetic purine derivative and cyclin-dependent kinase (CDK) inhibitor targeting Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1. By blocking CDK-dependent phosphorylation, it disrupts cell cycle progression and downstream signaling pathways involved in cellular proliferation. Treatment with Bohemine leads to the suppression of cancer cell growth, induction of cell cycle arrest, and stimulation of apoptotic cell death. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 68 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Intervirology. 1997;40(5-6):408-408.

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Note: Technical data last updated: Sep 1, 2026.