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Antalarmin hydrochloride CRFR antagonist

Name: Antalarmin hydrochloride
Brand: Selleck Chemicals
SKU: E6536
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E6536

Antalarmin hydrochloride is an orally active, non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist exhibiting a Ki value of 1 nM. This compound inhibits CRH-induced ACTH secretion and attenuates CRH-mediated and novelty-induced anxiety-like behaviors in preclinical models. Additionally, antalarmin hydrochloride demonstrates anti-inflammatory activity in arthritis models and reduces stress-induced gastric ulceration associated with irritable bowel syndrome.

Chemical Structure

Molecular Weight: 415.01

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Quality Control

Related Targets	Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras GPR GluR Prostaglandin Receptor CXCR Adenosine Receptor P2 Receptor CCR Angiotensin Receptor Hedgehog/Smoothened S1P Receptor PKA Cannabinoid Receptor cAMP Glucagon Receptor SGLT Opioid Receptor Sigma Receptor PAR Endothelin Receptor LTR Neurokinin Receptor Guanylate Cyclase PKG LPA Receptor

Chemical Information, Storage & Stability

Molecular Weight	415.01	Formula	C24H35ClN4	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	220953-69-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

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In vivo
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Mechanism of Action

In vivo	Antalarmin hydrochloride (5, 10, 20 mg/kg, i.p., single dose) blocks CRF-induced anxiety-like behavior and reduces defensive withdrawal in rats.
References	[1] https://pubmed.ncbi.nlm.nih.gov/8940412/ [2] https://pubmed.ncbi.nlm.nih.gov/12376179/ [3] https://pubmed.ncbi.nlm.nih.gov/9886810/ [4] https://pubmed.ncbi.nlm.nih.gov/15944267/

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