Home GPCR & G Protein CRFR

CRFR

Other GPCR & G Protein Related Inhibitors

Hedgehog/Smoothened PKA CGRP Receptor Endothelin Receptor S1P Receptor Cannabinoid Receptor SGLT Opioid Receptor GPR CCR
Cat.No. Product Name Information Product Use Citations Product Validations
E6536New Antalarmin hydrochloride Antalarmin hydrochloride is an orally active, non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist exhibiting a Ki value of 1 nM. This compound inhibits CRH-induced ACTH secretion and attenuates CRH-mediated and novelty-induced anxiety-like behaviors in preclinical models. Additionally, antalarmin hydrochloride demonstrates anti-inflammatory activity in arthritis models and reduces stress-induced gastric ulceration associated with irritable bowel syndrome.