CAS No. 869185-85-3
Batch:
Purity:98.26
Chemical Structure
Check the
Adezmapimod hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine;hydrochloride | |
|---|---|---|
| CAS Number | 869185-85-3 | |
| Molecular Formula |
C21H16FN3OS.ClH |
|
| Molecular Weight (MW) | 413.90 | |
| InChIKey | WOSGGXINSLMASH-UHFFFAOYSA-N |
Adezmapimod hydrochloride (SB 203580 hydrochloride) is a pyridinyl imidazole inhibitor of p38 mitogen-activated protein kinase (MAPK) family members, specifically targeting stress-activated protein kinase 2a (SAPK2a/p38) and SAPK2b/p38β2. By blocking p38 MAPK catalytic activity, it suppresses downstream activation of transcription factors and inflammatory signaling pathways, leading to the inhibition of pro-inflammatory cytokine biosynthesis such as TNF-α and IL-1β in chronic inflammatory disease models. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 4 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.