Ursolic Acid

For research use only.

Catalog No.S2370 Synonyms: NSC 167406, NSC-4060, Prunol, Urson, Malol

5 publications

Ursolic Acid Chemical Structure

CAS No. 77-52-1

Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.

Selleck's Ursolic Acid has been cited by 5 publications

Purity & Quality Control

Biological Activity

Description Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.
In vitro

Ursolic acid(Malol) is a pentacyclic triterpene acid, used in cosmetics, that is also capable of inhibiting various types of cancer cells by inhibiting the STAT3 activation pathway and human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9 by acting through the glucocorticoid receptor. As medicine, it is well tolerated and can be used topically and orally. Ursolic acid can also serve as a starting material for synthesis of more potent bioactive derivatives, such as anti-tumor agents. [1]

Assay
Methods Test Index PMID
Western blot
p-AKT / MDM2 / TOPK / p-TOPK ; 

PubMed: 26582056     


(d) Ursolic acid inhibited phosphorylation of Akt and expression of MDM2 in MCF-7 cells (upper panel). The cells were treated with various concentrations of ursolic acid for 24 h, and phosphor-Akt and MDM2 expression were analyzed by Western blotting. (e) Ursolic acid inhibited phosphorylation of TOPK (upper panel). The cells were treated with various concentrations of ursolic acid for 24 h, and total and phosphor-TOPK were analyzed by Western blotting.

p21; 

PubMed: 26582056     


Ursolic acid induced a concentration dependent up-regulation of p21 in MCF-7 cells. The cells were treated with various concentrations of ursolic acid for 24 h and p21 expression was measured by Western blotting. 

KRAS(G12V) / p-B-Raf / B-Raf / p-MEK / MEK / p-ERK / ERK ; 

PubMed: 27472952     


Ursolic acid inhibited protein phosphorylation of BRAF, MEK1/2, ERK1/2 of the MAPK signaling pathway in SW620 and RKO cells in a dose-dependent manner.

p-IKKα / IKKα / p-IκBα / IκBα / p-p65 / p65 ; 

PubMed: 27472952     


Ursolic acid inhibited protein phosphorylation of IKKα, IκBα, and p65 of the NF-κB signaling pathway in SW620 and RKO cells in a dose-dependent manner.

p-NF-κB / NF-κB ; 

PubMed: 27472952     


SW620 and RKO cells were treated with ursolic acid or oxaliplatin alone or in combination for 48 h and the phosphorylation status of ERK1/2, AKT, and IKKα was analyzed by Western blotting.

E-cadherin / Vimentin / N-cadherin / Twist / β-catenin / p-GSK3β / Cyclin D1 ; 

PubMed: 28090191     


The effect of ursolic acid on EMT (Twist, E-cadherin, N-cadherin, β-catenin, pGSKα/β) and survival proteins (cyclin D1, p-AKT, NFkB) by Western blotting. Ursolic acid was treated mesothelioma cells for 24 h and subjected to Western blotting for EMT and survival proteins. 

26582056 27472952 28090191
Growth inhibition assay
Cell viability; 

PubMed: 27472952     


Ursolic acid inhibited proliferation of the four CRC cell lines in dose- and time-dependent manners as determined by MTT assay.

27472952

Protocol

Solubility (25°C)

In vitro DMSO 91 mg/mL (199.25 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 456.7
Formula

C30H48O3

CAS No. 77-52-1
Storage powder
in solvent
Synonyms NSC 167406, NSC-4060, Prunol, Urson, Malol
Smiles CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Related Others Products

Tags: buy Ursolic Acid | Ursolic Acid supplier | purchase Ursolic Acid | Ursolic Acid cost | Ursolic Acid manufacturer | order Ursolic Acid | Ursolic Acid distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID