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Sesamin

Cat.No.S2392

Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.
Sesamin Chemical Structure

Chemical Structure

Molecular Weight: 354.35

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Quality Control

Batch: Purity: 99.86%
99.86

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 354.35 Formula

C20H18O6

 Storage (From the date of receipt)
CAS No. 607-80-7 Download SDF Storage of Stock Solutions

Synonyms Fagarol, Fsesamin Smiles C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6

Mechanism of Action

In vitro
Sesamin (Fagarol) is a lignan isolated from the bark of Fagara plants and from sesame oil. It has been used as a dietary fat-reduction supplement. This compound truly increases fat metabolism. It specifically inhibits delta 5 desaturase at low concentrations in polyunsaturated fatty acid biosynthesis in both microorganisms and animals, but does not inhibit delta 6, delta 9 and delta 12 desaturases. Dietary sesamin greatly increases the hepatic activity of fatty acid oxidation enzymes, including carnitine palmitoyltransferase, acyl-CoA dehydrogenase, acyl-CoA oxidase, 3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and 3-ketoacyl-CoA thiolase. This compound also increases the activity of 2,4-dienoyl-CoA reductase and delta3,delta2-enoyl-CoA isomerase, enzymes involved in the auxiliary pathway for beta-oxidation of unsaturated fatty acids dose-dependently. It is also a novel inhibitor of pregnane X receptor (PXR) and may be useful for modulating CYP3A4 and drug efficacies.
In vivo
LD50: Mice 3800mg/kg (i.g.); Rats 6150mg/kg (i.g.)
References
  • [4] http://link.springer.com/chapter/10.1007%2F978-1-4020-8804-9_14#

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05678439 Recruiting
Sleeping Disorders
Taipei Medical University
 November 18 2022 Not Applicable

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