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Guaifenesin

Cat.No.S1740

Guaifenesin is an expectorant used to relieve chest congestion. This compound works by thinning and loosening mucus in the airways, making it easier to cough up. It is commonly found in over-the-counter cold and cough medications.
Guaifenesin Chemical Structure

Chemical Structure

Molecular Weight: 198.22

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S174001 DMSO]40 mg/mL]false]Ethanol]40 mg/mL]false]Water]25 mg/mL]false Purity: 99.92%
99.92

Chemical Information, Storage & Stability

Molecular Weight 198.22 Formula

C10H14O4

Storage (From the date of receipt)
CAS No. 93-14-1 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC=CC=C1OCC(CO)O

Solubility

In vitro
Batch:

DMSO : 40 mg/mL (201.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 40 mg/mL

Water : 25 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

In vivo
Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. This compound (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. It (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. [1] This chemical (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. [2] It (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. [3] This compound prevents adverse anesthetic induction events caused by Propofol in horse. It (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. [4] This chemical (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. It (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. [5]
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/22126682/
  • [5] https://pubmed.ncbi.nlm.nih.gov/12444496/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03642262 Completed
Healthy Subjects
Reckitt Benckiser Inc.|Reckitt Benckiser LLC
 June 2 2013 Phase 1
NCT03649750 Completed
Healthy Subjects
Reckitt Benckiser LLC
 May 29 2013 Phase 1
NCT03633487 Completed
Healthy Subjects
Reckitt Benckiser LLC
 October 11 2011 Phase 1

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