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Guaifenesin

Name: Guaifenesin
Brand: Selleck Chemicals
SKU: S1740
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S1740

Guaifenesin is an expectorant used to relieve chest congestion. This compound works by thinning and loosening mucus in the airways, making it easier to cough up. It is commonly found in over-the-counter cold and cough medications.

Chemical Structure

Molecular Weight: 198.22

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Quality Control

Batch: S174001 DMSO]40 mg/mL]false]Ethanol]40 mg/mL]false]Water]25 mg/mL]false Purity: 99.92%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.92

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Solubility

In vitro
Batch:

DMSO : 40 mg/mL (201.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 40 mg/mL

Water : 25 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	198.22	Formula	C₁₀H₁₄O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	93-14-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	COC1=CC=CC=C1OCC(CO)O

Mechanism of Action

In vivo

Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. This compound (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. It (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. This chemical (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. It (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. This compound prevents adverse anesthetic induction events caused by Propofol in horse. It (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. This chemical (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. It (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice.

References

[1] https://pubmed.ncbi.nlm.nih.gov/3651894/
[2] https://pubmed.ncbi.nlm.nih.gov/18052732/
[3] https://pubmed.ncbi.nlm.nih.gov/11131605/

[4] https://pubmed.ncbi.nlm.nih.gov/22126682/
[5] https://pubmed.ncbi.nlm.nih.gov/12444496/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03642262	Completed	Healthy Subjects	Reckitt Benckiser Inc.\|Reckitt Benckiser LLC	June 2 2013	Phase 1
NCT03649750	Completed	Healthy Subjects	Reckitt Benckiser LLC	May 29 2013	Phase 1
NCT03633487	Completed	Healthy Subjects	Reckitt Benckiser LLC	October 11 2011	Phase 1

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