Guaifenesin

Catalog No.S1740

For research use only.

Guaifenesin is an expectorant used to relieve chest congestion.

Guaifenesin  Chemical Structure

CAS No. 93-14-1

Purity & Quality Control

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Biological Activity

Description Guaifenesin is an expectorant used to relieve chest congestion.
In vivo Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. [1] Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. [2] Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. [3] Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. [4] Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 40 mg/mL
(201.79 mM)
Ethanol 40 mg/mL
(201.79 mM)
Water 25 mg/mL
(126.12 mM)

Chemical Information

Molecular Weight 198.22
Formula

C10H14O4

CAS No. 93-14-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC=CC=C1OCC(CO)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03642262 Completed Drug: Mucinex® Healthy Subjects Reckitt Benckiser Inc.|Reckitt Benckiser LLC June 2 2013 Phase 1
NCT03649750 Completed Drug: Mucinex® Healthy Subjects Reckitt Benckiser LLC May 29 2013 Phase 1
NCT03633487 Completed Drug: Mucinex® Healthy Subjects Reckitt Benckiser LLC October 11 2011 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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