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Guaifenesin

Guaifenesin is an expectorant used to relieve chest congestion.

Guaifenesin Chemical Structure

Guaifenesin Chemical Structure

CAS: 93-14-1

Purity & Quality Control

Batch: S174001 DMSO] 40 mg/mL] false] Ethanol] 40 mg/mL] false] Water] 25 mg/mL] false Purity: 99.92%
99.92

Guaifenesin Related Products

Biological Activity

Description Guaifenesin is an expectorant used to relieve chest congestion.
In Vivo
In vivo Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. [1] Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. [2] Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. [3] Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. [4] Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03642262 Completed
Healthy Subjects
Reckitt Benckiser Inc.|Reckitt Benckiser LLC
 June 2 2013 Phase 1
NCT03649750 Completed
Healthy Subjects
Reckitt Benckiser LLC
 May 29 2013 Phase 1
NCT03633487 Completed
Healthy Subjects
Reckitt Benckiser LLC
 October 11 2011 Phase 1

Chemical Information & Solubility

Molecular Weight 198.22 Formula

C10H14O4

CAS No. 93-14-1 SDF Download Guaifenesin SDF
Smiles COC1=CC=CC=C1OCC(CO)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 40 mg/mL ( (201.79 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : 25 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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