CAS No. 173334-58-2

Batch: Purity:99.97
Check CoA
Aliskiren Hemifumarate Chemical Structure
Chemical Structure
Check the Aliskiren Hemifumarate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name bis((2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide);(E)-but-2-enedioic acid
CAS Number 173334-58-2
Molecular Formula

C30H53N3O6.1/2C4H4O4
Molecular Weight (MW) 609.83
SMILES CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O
InChIKey KLRSDBSKUSSCGU-KRQUFFFQSA-N

Ordering Information

Biological Activity

Aliskiren hemifumarate is a potent direct renin inhibitor that targets human renin within the renin-angiotensin-aldosterone system. By binding to the catalytic site of renin, it blocks the enzymatic cleavage of angiotensinogen to angiotensin I. This inhibition decreases downstream angiotensin II generation, suppressing arterial smooth muscle contraction and aldosterone secretion to regulate vascular tone and fluid balance.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 122 mg/mL (200.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 122 mg/mL
Ethanol 122 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.