3,3'-Dioctadecyloxacarbocyanine perchlorate

Catalog No.S3564 Synonyms: DiOC18(3), DIO

For research use only.

3,3'-Dioctadecyloxacarbocyanine perchlorate (DiOC18(3), DIO) is a green fluorescent lipophilic tracer, which is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes.

CAS No. 34215-57-1

Purity & Quality Control

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Biological Activity

Description 3,3'-Dioctadecyloxacarbocyanine perchlorate (DiOC18(3), DIO) is a green fluorescent lipophilic tracer, which is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes.

Protocol (from reference)

Chemical Information

Molecular Weight
Formula
CAS No. 34215-57-1
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05344963 Recruiting Drug: Sodium-GLucose coTransporter-2 inhibitors Sodium-GLucose coTransporter-2 Inhibitors|Heart Failure With Reduced Ejection Fraction Matteo Cameli|Fondazione Toscana G. Monasterio Pisa|Cardiology and Cardiovascular Pathophysiology - Heart Failure Unit; Santa Maria della Misericordia Hospital University of Perugia|Section of Cardiology Department of Medicine University of Verona Verona|Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore Rome|Cardiology and Arrhythmology Clinic Marche Polytechnic University 60121 Ancona|Cardiology Department Ospedale Guglielmo da Saliceto - Piacenza|University Cardiology Unit Cardiothoracic Department Polyclinic University Hospital Bari|ProMISE University Hospital Paolo Giaccone University of Palermo|Department of Cardiovascular Disease - AUSL Romagna Division of Cardiology Ospedale S. Maria Delle Croci Viale Randi 5 48121 Ravenna|Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia|Department of Biomedical Sciences for Health University of Milano Milan|Division of Cardiology ''A. De Gasperis'' Cardio Center ASST Grande Ospedale Metropolitano Niguarda Piazza Ospedale Maggiore 3 20162 Milan|Department of Advanced Biomedical Science Federico II University Hospital Naples|Department of Thoracic Heart and Vascular Diseases Maggiore della Carità Hospital Novara|Divisione di Cardiologia Ospedale S. Maria del Carmine Rovereto TN|ASST-Rhodense; Ospedale di Circolo di Rho|Cardio-Thoracic-Vascular Department. University Hospital San Giovanni di Dio e Ruggi d''Aragona. Salerno|Centro Medico Sant''Agostino Milano|Università Politecnica delle Marche Ospedali riuniti di Ancona|Department of Cardiology Policlinico Universitario Campus Bio-Medico Via Álvaro del Portillo 21 Roma|Azienda Ospedaliera Universitaria Senese April 1 2022 --
NCT04255433 Recruiting Drug: Tirzepatide|Drug: Dulaglutide Type 2 Diabetes Mellitus Eli Lilly and Company May 29 2020 Phase 3
NCT04271280 Active not recruiting Other: Non-interventional Dyslipidemic|Cardiovascular Diseases|Hypercholesterolemia|Atherosclerotic Cardiovascular Disease Daiichi Sankyo Europe GmbH a Daiichi Sankyo Company|Daiichi Sankyo Inc. March 17 2020 --
NCT03909386 Active not recruiting -- Atrial Fibrillation|Cancer Heart Care Foundation June 26 2019 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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