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NUDIX1 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7631 TH287 TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM. Selective MTH1, IC50: 0.8 nM
S7632 TH588 TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM. Selective MTH1, IC50: 5 nM
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay. Selective MTH1, IC50: 72 nM