NUDIX1 Selective Inhibitors

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S7631	TH287	TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.	Selective	MTH1, IC50: 0.8 nM
S7632	TH588	TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.	Selective	MTH1, IC50: 5 nM
S7505	(S)-crizotinib	(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.	Selective	MTH1, IC50: 72 nM