Home Endocrinology & Hormones Mineralocorticoid Receptor antagonist Finerenone For research use only.

Finerenone

Synonyms: FIN, BAY 94-8862

Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.

Finerenone Chemical Structure

Finerenone Chemical Structure

CAS: 1050477-31-0

Purity & Quality Control

Batch: Purity: 99.97%
99.97

Finerenone Related Products

Choose Selective Mineralocorticoid Receptor Inhibitors

Biological Activity

Description Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
Targets
MR [1]
(Cell-free assay)
18 nM
In vitro
In vitro

In vitro, Finerenone dose-dependently reduces aldosterone-induced smooth muscle cell (SMC) proliferation and prevents aldosteroneinduced endothelial cell (EC) apoptosis. Finerenone significantly reduces apoptosis of ECs and simultaneously attenuates SMC proliferation, resulting in accelerated endothelial healing and reduced neointima formation of the injured vessels.[2]
Cell Research Cell lines Human coronary artery smooth muscle cells (SMC), human umbilical vein endothelial cells (EC)
Concentrations 1 nM, 10 nM
Incubation Time 24 h
Method

Cells are incubated with aldosterone with or without finerenone for 24 hours after 24 hours of serum-starvation for the assessment of cell proliferation and apoptosis. Immediately prior to the addition of aldosterone, cells are preincubated with finerenone or vehicle for 30 minutes.
In Vivo
In vivo

Finerenone improves endothelial dysfunction through an enhancement in NO bioavailability and a decrease in superoxide anion levels due to an upregulation in SOD activity. This is associated with an increase in renal SOD activity and a reduction of albuminuria.[1]
Animal Research Animal Models 12-week-old MWF, aged-matched normoalbuminuric Wistar rats
Dosages 10 mg/kg
Administration Oral gavage
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06059664 Not yet recruiting
Kidney Transplant; Complications
University of North Carolina Chapel Hill|Bayer
 November 1 2023 Phase 2
NCT06116591 Recruiting
Healthy Participants
Pfizer
 November 8 2023 Phase 2

Chemical Information & Solubility

Molecular Weight 378.42 Formula

C21H22N4O3
CAS No. 1050477-31-0 SDF --
Smiles CCOC1=NC=C(C)C2=C1C(C3=CC=C(C=C3OC)C#N)C(=C(C)N2)C(N)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 76 mg/mL ( (200.83 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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