Finerenone

For research use only.

Catalog No.S9702 Synonyms: FIN, BAY 94-8862

Finerenone Chemical Structure

CAS No. 1050477-31-0

Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.

Purity & Quality Control

Choose Selective Mineralocorticoid Receptor Inhibitors

Biological Activity

Description Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
Targets
MR [1]
(Cell-free assay)
18 nM
In vitro

In vitro, Finerenone dose-dependently reduces aldosterone-induced smooth muscle cell (SMC) proliferation and prevents aldosteroneinduced endothelial cell (EC) apoptosis. Finerenone significantly reduces apoptosis of ECs and simultaneously attenuates SMC proliferation, resulting in accelerated endothelial healing and reduced neointima formation of the injured vessels.[2]

In vivo

Finerenone improves endothelial dysfunction through an enhancement in NO bioavailability and a decrease in superoxide anion levels due to an upregulation in SOD activity. This is associated with an increase in renal SOD activity and a reduction of albuminuria.[1]

Protocol

Cell Research:

[2]

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  • Cell lines: Human coronary artery smooth muscle cells (SMC), human umbilical vein endothelial cells (EC)
  • Concentrations: 1 nM, 10 nM
  • Incubation Time: 24 h
  • Method:

    Cells are incubated with aldosterone with or without finerenone for 24 hours after 24 hours of serum-starvation for the assessment of cell proliferation and apoptosis. Immediately prior to the addition of aldosterone, cells are preincubated with finerenone or vehicle for 30 minutes.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: 12-week-old MWF, aged-matched normoalbuminuric Wistar rats
  • Dosages: 10 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 76 mg/mL (200.83 mM)
Water Insoluble
Ethanol ''''10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 378.42
Formula

C21H22N4O3

CAS No. 1050477-31-0
Storage powder
in solvent
Synonyms FIN, BAY 94-8862

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05013008 Not yet recruiting Drug: Finerenone (BAY94-8862)|Drug: Placebo Chronic Kidney Disease|Type 2 Diabetes Mellitus Bayer August 24 2021 Phase 2
NCT04908202 Recruiting Drug: Deucravacitinib|Other: Placebo Psoriatic Arthritis Bristol-Myers Squibb July 13 2021 Phase 3
NCT04696523 Not yet recruiting Drug: Xenon|Drug: air/oxygen Subarachnoid Hemorrhage Aneurysmal|Cerebral Injury|Cerebral Ischemia|Cerebral Infarction|Cardiac Event|Cardiac Failure Turku University Hospital|Academy of Finland May 1 2021 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID