Mechanosensitive Channel Antagonists

Other Transmembrane Transporters Related Inhibitors

CFTR CRM1 Calcium Channel Proton Pump P-gp Sodium Channel ATPase Potassium Channel CD markers GLUT

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S2953	Dooku1	Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. This compound inhibits 2 μM Yoda1-induced Ca²⁺-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.	Cancers (Basel), 2026, 18(5)827 bioRxiv, 2026, nan Science Advances, 2023, eadg0478

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S2953

Dooku1

Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. This compound inhibits 2 μM Yoda1-induced Ca²⁺-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.

Cancers (Basel), 2026, 18(5)827

bioRxiv, 2026, nan

Science Advances, 2023, eadg0478