Mechanosensitive Channel Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S2953 Dooku1 Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. This compound inhibits 2 μM Yoda1-induced Ca2+-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.
Sci Adv, 2023, 9(22):eadg0478