HCN Channel

Other Neuronal Signaling Related Inhibitors

Secretase GluR GABA Receptor Dopamine Receptor 5-HT Receptor P2 Receptor AChR Histamine Receptor MAO Beta Amyloid

Cat.No.	Product Name	Information	Product Use Citations
E1260	ZD7288	ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.
E7929	Zatebradine hydrochloride	Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively.
S2086	Ivabradine HCl	Ivabradine HCl (S 16257-2,S-18982 D6 hydrochloride), a new I_f inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.	Cell Rep, 2022, 38(10):110468 J Pain, 2018, 19(6):626-634

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

E1260

ZD7288

ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.

E7929

Zatebradine hydrochloride

Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively.

S2086

Ivabradine HCl

Ivabradine HCl (S 16257-2,S-18982 D6 hydrochloride), a new I_f inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

Cell Rep, 2022, 38(10):110468

J Pain, 2018, 19(6):626-634