Antibiotics Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
E4996	Puromycin	Puromycin (CL13900, Puromycine) is an antibiotic, analog of the 3' end of aminoacyl-tRNA and an inhibitor of protein synthesis that mimics tyrosyl-tRNA, causing premature termination of translation. It blocks translation by labeling and releasing elongating polypeptide chains from ribosomes and has been widely used in molecular biology research.	Adv Sci (Weinh), 2026, 13(20):e19586 Nat Genet, 2025, 57(3):680-693 Nat Commun, 2025, 16(1):10324
E2894	Penicillin-Streptomycin	Penicillin-Streptomycin is used to prevent microbial contamination of cell culture during long-term in vitro cell culture maintenance. 100× solution stabilized with 10,000 units penicillin and 10 milligrams streptomycin per milliliter, suitable for cell culture applications.	Mol Cancer, 2026, 25(1)95 PLoS One, 2026, 21(2):e0342565 Mol Ther, 2025, S1525-0016(25)00543-X
S2527	Methacycline HCl	Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.	iScience, 2024, 27(10):110862 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S4783	Benzyl isothiocyanate	Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.	Biomolecules and Therapeutics, July 1, 2022, 30(4):348-359 Biomolecules, December 6, 2019, 9(12):839 Biomol Ther (Seoul), 2022, 30(4):348-359
E7524	G-418	G-418 (Geneticin, Antibiotic G-418) is an aminoglycoside antibiotic originally isolated from Micromonospora rhodorangea. It functions by binding to the ribosomal subunit, thereby inhibiting translational elongation and disrupting protein synthesis in both prokaryotic and eukaryotic cells, thus impairing cell growth and viability.	Molecular Therapy - Oncolytics, March 29, 2020, 21-30 International Journal of Molecular Sciences, June 23, 2025, 6009
S1611	Cefoperazone	Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [³H]E₂17βG uptake with IC50 of 199 μM.	Microbiology Spectrum, 2023, e0470222
S4974	Oxacillin sodium	Oxacillin sodium (salt) is a narrow-spectrum β-lactam antibiotic that can be used for treatment of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia.
E8298	Duocarmycin SA	Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. It is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA and can be used in research treatment for glioblastoma multiforme (GBM).
S4979	Procaine penicillin G	Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic.
S4941	Farnesol	Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects.
E2890	CHIR-090	CHIR-090 is a potent and tight-binding inhibitor of the LpxC deacetylase. It also binds to E. coli LpxC with a Ki of 4.0 nM.
E0656	7-Methylcoumarin	7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.
S4488	Delafloxacin Meglumine	Delafloxacin (ABT-492, RX-3341, WQ-3034, Baxdela) meglumine is a broad-spectrum fluoroquinolone antibiotic against multiple pathogens.
S7417	Puromycin Dihydrochloride	Puromycin 2HCl is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinated expression of genes during cell differentiation.	Autophagy, October 6, 2021, 1-12 Nucleic Acids Research, March 20, 2025, gkaf200 Nature Communications, December 5, 2024, 10594
S7046	Brefeldin A (BFA chemical)	Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.	Protein Cell, 2025, pwaf020 Cancer Commun (Lond), 2025, 10.1002/cac2.70036 J Integr Plant Biol, 2025, 67(8):2229-2244
S1228	Idarubicin HCl	Idarubicin HCl (4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. Idarubicin induces mTOR-dependent cytotoxic autophagy.	Blood Cancer Discov, 2025, 10.1158/2643-3230.BCD-24-0327 Blood Cancer Discov, 2025, 6(5):464-483 Biochem Pharmacol, 2025, 237:116914
S4490	Tetracycline	Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.	Nature Communications, December 20, 2023, 8455 Journal of Gastrointestinal Oncology, April 2021, 694-710 Redox Biol, 2025, 84:103649
S5008	Ciprofloxacin (CPX) hydrochloride	Ciprofloxacin (CPX) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).	Journal of Biological Chemistry, 2025, 110653 Journal of Clinical Investigation, 2022, e152345 Nanomaterials (Basel), 2021, 11(8)1984
S5199	Oxytetracycline hydrochloride	Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.	Front Microbiol, 2016, 7:1765
S3496	Lefamulin acetate (Xenleta)	Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. It inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.	Journal of Biological Chemistry, 2022 May, 101909 J Biol Chem, 2022, 298(5):101909 Journal of Biological Chemistry, 2022, 101909
S7784	Fumagillin	Fumagillin(Amebacilin,NSC9168) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.	International Journal for Parasitology: Drugs and Drug Resistance, 2023, 19-27
S6549	PBTZ169	PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1.	Cell Death Dis, 2019, 10(4):319
S4436	Pleuromutilin	Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.	npj Antimicrobials and Resistance, 2025, 25
S1791	Bacitracin Zinc	Bacitracin(Zinc Bacitracin) is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
S4647	Cefmenoxime hydrochloride	Cefmenoxime (SCE-1365), a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly.
S6584	Amdinocillin	Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. This compound is active alone against many gram-negative organisms.
S4425	Rifamycin S	Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. This compound generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.