Home Stem Cells & Wnt Wnt/beta-catenin

Wnt/beta-catenin Activators

Cat.No. Product Name Information Product Use Citations Product Validations
S8178 BML-284 Hydrochloride (Wnt agonist 1, AMBMP) BML-284 (Wnt agonist 1) is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.
EMBO Mol Med, 2025, 17(7):1794-1824
Mol Psychiatry, 2025, 30(12):5731-5748
Oncol Rep, 2025, 53(1)7
Verified customer review of BML-284 Hydrochloride (Wnt agonist 1, AMBMP)
S3630 Methyl Vanillate Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
Sci Rep, 2022, 12(1):7
E4800 BML-284 BML-284 (Wnt Agonist) is a potent and cell-permeable activator of Wnt signaling that induces TCF-dependent transcriptional activity with an EC50 value of 0.7 µM. This compound also acts as an agonist of β-catenin that effectively activates direct Wnt-β-catenin signaling to induce adipocyte dedifferentiation while circumventing the apoptotic effect in the hypertonic treatment.
S1263 CHIR-99021 (Laduviglusib) Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 values of 10 nM and 6.7 nM, respectively. It does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. This compound functions as a Wnt/β-catenin activator and induces autophagy.
Cancer Cell, 2025, 43(4):776-796.e14
Circulation, 2025, 151(20):1436-1448
Nat Biomed Eng, 2025, 9(1):93-108
Verified customer review of CHIR-99021 (Laduviglusib)
S2924 Laduviglusib (CHIR-99021) Hydrochloride Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.
Cell, 2025, 188(11):2974-2991.e20
Cell, 2025, S0092-8674(25)00807-4
Protein Cell, 2025, pwaf098
Verified customer review of Laduviglusib (CHIR-99021) Hydrochloride
S7954 CP21R7 CP21R7 is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.
Am J Transl Res, 2025, 17(10):8060-8075
J Nanobiotechnology, 2024, 22(1):373
iScience, 2024, 27(10):110862
S7421 CGP 57380 CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. This compound upregulates β-catenin and potentiates radiation-induced apoptosis.
Journal of Cancer, January 1, 2020, 990-996
International Journal of Oncology, February 2020, 430-438
Translational Cancer Research, April 2020, 2588-2598
Verified customer review of CGP 57380
S7914 ISX-9 (Isoxazole 9) Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial–mesenchymal transition (EMT) signaling, canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.
iScience, 2025, 28(3):112015
Front Cell Dev Biol, 2025, 13:1513163
Cell Regen, 2025, 14(1):18
S3223 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. This compound upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
E0072 Indirubin-3′-oxime Indirubin-3′-oxime (IDR3O, I3O) is an indirubin analogue that shows favorable inhibitory activity targeting GSK-3β and CDKs. This compound also inhibits JNKs with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM for JNK1, JNK2, and JNK3, respectively. It activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
S6085 KY19382 (A3051) KY19382 (A3051) is a Wnt/β-catenin signalling activator through inhibitory effects on both CXXC5–DVL interaction and GSK3β activity with IC50s of 19 nM and 10 nM, respectively.