Wnt/beta-catenin Agonists

Cat.No.	Product Name	Information	Product Use Citations
S8320	SKL2001	SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction.	J Exp Clin Cancer Res, 2025, 44(1):19 Cancer Cell Int, 2025, 25(1):348 Nat Cancer, 2024, 10.1038/s43018-023-00716-7
S9828	WAY-262611	WAY-262611 (BML-WN110, Compound 5) is a beta-catenin (β-Catenin) agonist that increases bone formation rate with EC50 of 0.63 μM in TCF-Luciferase assay. This compound is also an inhibitor of dickkopf 1 (DKK1).	J Transl Med, 2025, 23(1):986 Cell Mol Life Sci, 2024, 81(1):260 J Orthop Surg Res, 2023, 18(1):751
S2745	CHIR-98014	CHIR-98014 (CT98014) is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.	Med Oncol, 2025, 42(8):333 Stem Cell Res, 2025, 87:103797 Commun Med (Lond), 2025, 5(1):323
S5815	WAY-316606	WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.	Stem Cells Translational Medicine, 2024, 399-413 Stem Cells Transl Med, 2024, szae006 Journal of Oral Health and Biosciences, 2023, Vol. 35, No. 2, pp. 52-60