Wnt/beta-catenin Antagonists

Cat.No.	Product Name	Information	Product Use Citations
S8968	PRI-724 (Foscenvivint)	Foscenvivint (PRI-724) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.	Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0629 Cell Death Dis, 2025, 16(1):466 Biomed Pharmacother, 2025, 188:118225
S8647	iCRT3	iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays.	iScience, 2025, 28(5):112398 Front Cell Dev Biol, 2024, 12:1302141 Cell Div, 2024, 19(1):25
S0733	Tegatrabetan (BC-2059)	Tegatrabetan (BC-2059, Tegavivint), an antagonist of β-Catenin, disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation, leading to declines in the nuclear levels of β-catenin.	Nucleic Acids Res, 2024, 52(9):4950-4968 Cell Rep, 2024, 43(8):114532 J Transl Med, 2024, 22(1):201
S8462	Toxoflavin	PKF118-310 is a potent antagonist of transcription factor 4 (TCF4)/β-catenin signaling, and also an inhibitor of KDM4A . It exhibits anticancer activity and can be used in solid tumor research.