Wnt/beta-catenin Modulators

Cat.No.	Product Name	Information	Product Use Citations
S0458	KY1220	KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
S5992	Heparan Sulfate	Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.	Mol Ther Methods Clin Dev, 2025, 33(1):101426 iScience, 2024, 27(6):110120 bioRxiv, 2024, 2024.05.23.595417
S6961	Foxy-5	Foxy-5, a Wnt-5a mimicking hexapeptide, is a WNT signalling pathway modulator potentially for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer.	Journal of Nanobiotechnology, March 23, 2024, 128 Journal of Nanobiotechnology, March 23, 2024, 22(1):128 CNS Neuroscience & Therapeutics, February 8, 2023, 29(5):1254-1271

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S0458

KY1220

KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.

S5992

Heparan Sulfate

Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.

Mol Ther Methods Clin Dev, 2025, 33(1):101426

iScience, 2024, 27(6):110120

bioRxiv, 2024, 2024.05.23.595417

S6961

Foxy-5

Foxy-5, a Wnt-5a mimicking hexapeptide, is a WNT signalling pathway modulator potentially for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer.

Journal of Nanobiotechnology, March 23, 2024, 128

Journal of Nanobiotechnology, March 23, 2024, 22(1):128

CNS Neuroscience & Therapeutics, February 8, 2023, 29(5):1254-1271