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P-gp Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S8028 Tariquidar (XR9576) Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.
Nat Commun, 2025, 16(1):5511
J Transl Med, 2025, 23(1):542
Cells, 2025, 14(16)1276
Verified customer review of Tariquidar (XR9576)
S7772 Elacridar (GF120918) Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.
Nat Commun, 2025, 16(1):5511
Cell Rep Med, 2025, 6(6):102160
Nanoscale, 2025, 17(16):9947-9962
Verified customer review of Elacridar (GF120918)
S4746 (20S)-Protopanaxadiol 20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.
Front Pharmacol, 2025, 16:1530270
S9145 Solamargine Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.
Sci Rep, 2016, 6:36721
S3235 Sinapine Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. This compound inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.
Gene, 2022, 827:146460
S0921 Wilforine Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
S3431 Encequidar (HM30181) Encequidar (HM30181, HM30181A) is a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp).
S9563 Evodine Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. This compound is a potent P-gp inhibitor.
E1742 Reversan Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
S4202 Verapamil HCl Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
Cancer Cell, 2025, 43(4):776-796.e14
Nat Commun, 2025, 16(1):7115
Blood Sci, 2025, 7(2):e00236
Verified customer review of Verapamil HCl
S7124 SC144 SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Respir Res, 2025, 26(1):285
bioRxiv, 2025, 2025.01.20.633954
Verified customer review of SC144
S3600 Schisandrin B Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
Phytomedicine, 2025, 141:156672
Front Pharmacol, 2025, 16:1547685
Sci Rep, 2025, 15(1):8452
E4980 Verapamil Verapamil(Iproveratril,Dilacoran), is a phenylalkylamine derivative which is an antagonist of calcium influx and also an inhibitor P-gp and CYP3A4. It exhibits potency in treatment for angina, cardiac arrhythmias, cardiomyopathies and hypertension.
Nat Commun, 2025, 16(1):8069
J Am Heart Assoc, 2025, 14(1):e037400
Pharmaceuticals (Basel), 2025, 18(2)181