P-gp Modulators

Cat.No.	Product Name	Information	Product Use Citations
S1481	Zosuquidar 3HCl	Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance with K_i of 60 nM in a cell-free assay. Phase 3.	bioRxiv, 2025, 2025.06.18.660465 Hepatol Commun, 2024, 8(5)e0437 Adv Healthc Mater, 2022, e2201984
E1781	Biricodar	Biricodar(VX-710) is a modulator of P-glycoprotein and MRP-1 with minimal in vivo toxicity. It enhances the effectiveness of various antibiotics against numerous gram-positive pathogens and exhibits potent chemosensitizing properties in cells resistant to multiple drugs.
S9201	Levistilide A	Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
S4662	Atazanavir	Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. This compound is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.	Int J Mol Sci, 2022, 23(23)15380 Chemistry, 2022, e202202798. Cells, 2021, 10(12)3458