Zinc Pyrithione

Catalog No.S4075 Synonyms: OM-1563

Zinc Pyrithione Chemical Structure

Molecular Weight(MW): 317.7

Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.
Targets
Proton pump [1]
In vitro

Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. [1] Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential. [2]

In vivo Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50) = 8.27 μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed. [3]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (94.42 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 317.7
Formula

C10H8N2O2S2Zn

CAS No. 13463-41-7
Storage powder
Synonyms OM-1563

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Proton Pump Signaling Pathway Map

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