Catalog No.S4013 Synonyms: NSC248
Molecular Weight(MW): 143.95
Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.
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|Description||Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.|
Monofluorophosphate (1 mM) induces a three-fold increase in proliferation rate of embryonic chick calvarial cells in serum-free monolayer cultures. 30 μM of Monofluorophosphate increases the activity of DNA and alkaline phosphatase in calvarial cells by 135% and 178%, respectively. In cultured intact calvaria, 30 μM of Monofluorophosphate increases DNA activity, alkaline phosphatase activity and collagen production by 143%, 186% and 151%, respectively. 
|In vivo||Monofluorophosphate displays potent activity on bone immobilization in vivo. Rats supplied with drinking water containing 50 ppm F as Monofluorophosphate show a significant increase in the bone sickness of mobile tibia and immobile tibia, compared with fluoride-free water group (1.48 vs 0.98 mm, 0.79 vs 0.40 mm, respectively). Monofluorophosphate does not change the specific gravities of the immobilized and non-immobilized tibiae of the rats. Administration of Monofluorophosphate increases the mineralization rate of bones and counteracts the decrease in bone thickness, ash content and specific gravity induced by immobilization, without changing the Ca/P ratio of the ash. |
|In vitro||Water||29 mg/mL (201.45 mM)|
|DMSO||slightly soluble or insoluble|
|Ethanol||slightly soluble or insoluble|
|In vivo||Add solvents individually and in order:
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02937636||Not yet recruiting||Gingivitis||GlaxoSmithKline||February 2017||--|
|NCT02924350||Not yet recruiting||Dentin Sensitivity||GlaxoSmithKline||November 2016||--|
|NCT02923895||Completed||Dentin Sensitivity||GlaxoSmithKline||October 2016||Phase 4|
|NCT02861664||Completed||Dentin Sensitivity||GlaxoSmithKline||September 2016||--|
|NCT02768194||Not yet recruiting||Dentin Sensitivity||GlaxoSmithKline||June 2016||--|
|NCT02940821||Active, not recruiting||Dental Plaque|Gingivitis||Pearl Network||June 2016||--|
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