Sodium Monofluorophosphate

Catalog No.S4013 Synonyms: NSC248

Sodium Monofluorophosphate   Chemical Structure

Molecular Weight(MW): 143.95

Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.
Targets
alkaline phosphatase [1] phosphorylase phosphatase [1] pyruvate kinase [1]
69 μM(Ki) 0.5 mM(Ki) 3.4 mM(Ki)
In vitro

Monofluorophosphate (1 mM) induces a three-fold increase in proliferation rate of embryonic chick calvarial cells in serum-free monolayer cultures. 30 μM of Monofluorophosphate increases the activity of DNA and alkaline phosphatase in calvarial cells by 135% and 178%, respectively. In cultured intact calvaria, 30 μM of Monofluorophosphate increases DNA activity, alkaline phosphatase activity and collagen production by 143%, 186% and 151%, respectively. [2]

In vivo Monofluorophosphate displays potent activity on bone immobilization in vivo. Rats supplied with drinking water containing 50 ppm F as Monofluorophosphate show a significant increase in the bone sickness of mobile tibia and immobile tibia, compared with fluoride-free water group (1.48 vs 0.98 mm, 0.79 vs 0.40 mm, respectively). Monofluorophosphate does not change the specific gravities of the immobilized and non-immobilized tibiae of the rats. Administration of Monofluorophosphate increases the mineralization rate of bones and counteracts the decrease in bone thickness, ash content and specific gravity induced by immobilization, without changing the Ca/P ratio of the ash. [3]

Protocol

Solubility (25°C)

In vitro Water 29 mg/mL (201.45 mM)
DMSO <1 mg/mL
Ethanol <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 143.95
Formula

FNa2O3P

CAS No. 10163-15-2
Storage powder
in solvent
Synonyms NSC248

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02937636 Not yet recruiting Gingivitis GlaxoSmithKline February 2017 --
NCT02924350 Not yet recruiting Dentin Sensitivity GlaxoSmithKline November 2016 --
NCT02923895 Completed Dentin Sensitivity GlaxoSmithKline October 2016 Phase 4
NCT02861664 Completed Dentin Sensitivity GlaxoSmithKline September 2016 --
NCT02768194 Not yet recruiting Dentin Sensitivity GlaxoSmithKline June 2016 --
NCT02940821 Active, not recruiting Dental Plaque|Gingivitis Pearl Network June 2016 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID