Home Transmembrane Transporters Proton Pump inhibitor Pantoprazole sodium

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Pantoprazole sodium Proton Pump inhibitor

Cat.No.S4538

Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
Pantoprazole sodium Proton Pump inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 405.35

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Quality Control

Batch: Purity: 99.85%
99.85

Solubility

In vitro
Batch:

DMSO : 81 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 81 mg/mL

Ethanol : 81 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
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% ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 405.35 Formula

C16H14F2N3NaO4S

 Storage (From the date of receipt)
CAS No. 138786-67-1 Download SDF Storage of Stock Solutions

Synonyms SKF96022 sodium, BY-1023 sodium Smiles COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]

Mechanism of Action

Targets/IC50/Ki
Proton pump
HIF-1α
(H+/K+)-ATPase
In vitro
pantoprazole (PPZ) inhibits tumor cells proliferation, inducs apoptosis and decreases the expression of HIF-1α protein. Pantoprazole affects the intracellular distribution of HIF-1α in SGC-7901 cells, which might be one of the mechanisms of its chemosensitizing effect on cancer cells.
In vivo
After PPZ treatment, apoptotic cell death is seen selectively in cancer cells and is accompanied with extracellular signal-regulated kinase deactivation. By contrast, normal gastric mucosal cells show the resistance to PPZ-induced apoptosis through the overexpression of antiapoptotic regulators including HSP70 and HSP27. In a xenograft model of nude mice, administration of PPZ significantly inhibits tumorigenesis and induces large-scale apoptosis of tumor cells.
References
  • [1] https://pubmed.ncbi.nlm.nih.gov/26870273/
  • [2] https://pubmed.ncbi.nlm.nih.gov/22248271/
  • [3] https://www.researchgate.net/publication/288803659_Effect_of_pantoprazole_on_hypoxia-inducible_factor-1a_expression_in_human_gastric_adenocarcinoma_cell_line_SGC-7901
  • [4] https://pubmed.ncbi.nlm.nih.gov/15623654/

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