Panaxatriol

Catalog No.S3847 Batch:S384701

Technical Data

Formula	C₃₀H₅₂O₄
Molecular Weight	476.73	CAS No.	32791-84-7
Solubility (25°C)*	In vitro	DMSO	95 mg/mL (199.27 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities.
In vitro	Panaxatriol exerts dose-dependent cytotoxic effects on prostate DU-15 cancer cells. The IC50 of panaxatriol is 30 μM. Panaxatriol is found to exert its anticancer activity through induction of apoptosis. The apoptosis of DU-15 cancer cells is prompted by ROS-mediated alterations in mitochondrial membrane potential. Additionally, panaxatriol induces sub-G1 cell cycle arrest and suppresses the DU-15 cell migration ability in a concentration-dependent manner^[1].
In vivo	Panaxatriol can relieve myelosuppression induced by radiation injury^[2].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines DU-15 cancer cells Concentrations 0-120 μM Incubation Time 48-72 h Method The cytotoxic effect of panaxatriol against prostate cancer cells is determined by MTT assay. DU-15 cells are cultured at the density of 1×10⁶ cells per well in 96 well plates for 12 hrs and then treated with varying concentrations of panaxatriol (0-120 μM) for 48-72 hrs. MTT solution (20 μl) is added to each well. After-wards, 500 μl of DMSO is added to solubilize MTT formazan crystals, and ELISA plate reader is used for the determination of optical density.
Animal Study:^{^[2]}	Animal Models albino mice Dosages 200 mg/kg Administration oral administration

Cell Assay:^{^[1]}

Cell lines
DU-15 cancer cells
Concentrations
0-120 μM
Incubation Time
48-72 h
Method
The cytotoxic effect of panaxatriol against prostate cancer cells is determined by MTT assay. DU-15 cells are cultured at the density of 1×10⁶ cells per well in 96 well plates for 12 hrs and then treated with varying concentrations of panaxatriol (0-120 μM) for 48-72 hrs. MTT solution (20 μl) is added to each well. After-wards, 500 μl of DMSO is added to solubilize MTT formazan crystals, and ELISA plate reader is used for the determination of optical density.

Animal Study:^{^[2]}

Animal Models
albino mice
Dosages
200 mg/kg
Administration
oral administration

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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