Catalog No.S7453

MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2.

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MSDC-0160 Chemical Structure

MSDC-0160 Chemical Structure
Molecular Weight: 370.42

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Description MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2.
Targets mTOT [1]
In vitro MSDC-0160 reduces resistance in the insulin/IGF-1 signaling pathway and restores IGF-1-induced Akt and GSK-3 phosphorylation. MSDC-0160 in combination with IGF-1 and 8 mM glucose increases β-cell specific gene expression of insulin, pdx1, nkx6.1, and nkx2.2, and maintains insulin content without altering glucose-stimulated insulin secretion. Furthermore, MSDC-0160 promotes human β-cell differentiation and reduces the expression of markers of apoptosis. [1]
In vivo MSDC-0160 (100 mg/kg p.o.) improves insulin sensitivity by resulting in the large decrease in the product of circulating insulin and glucose in diabetic KKAy mice. [2]

Protocol(Only for Reference)

Animal Study: [2]

Animal Models Diabetic KKAy mice
Formulation Suspended in 1% sodium methyl carboxycellulose/0.01% Tween 20.
Dosages ~100 mg/kg
Administration p.o.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Rohatgi N, et al. PLoS One. 2013, 8(5), e62012.

[2] Bolten CW, et al. Gene Regul Syst Bio. 2007, 1, 73-82.

Clinical Trial Information( data from, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT01374438 Completed Alzheimers Disease Metabolic Solutions Development Company July 2011 Phase 2
NCT00760578 Completed Type 2 Diabetes Mellitus Metabolic Solutions Development Company September 2008 Phase 2

Chemical Information

Download MSDC-0160 SDF
Molecular Weight (MW) 370.42

C19 H18 N2 O4 S

CAS No. 146062-49-9
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms CAY10415
Solubility (25°C) * In vitro DMSO 0.01 mg/mL (0.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2,​4-​Thiazolidinedione, 5-​[[4-​[2-​(5-​ethyl-​2-​pyridinyl)​-​2-​oxoethoxy]​phenyl]​methyl]​-

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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