Home Apoptosis IGF-1R modulator MSDC-0160

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MSDC-0160 IGF-1R modulator

Cat.No.S7453

MSDC-0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2.
MSDC-0160 IGF-1R modulator Chemical Structure

Chemical Structure

Molecular Weight: 370.42

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Quality Control

Batch: S745301 0.5MNAOH]3.03 mg/mL]false]DMSO]0.01 mg/mL]false]Water]Insoluble]false Purity: 99.45%
99.45

Solubility

In vitro
Batch:

0.5MNAOH : 3.03 mg/mL

DMSO : 0.01 mg/mL (0.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 370.42 Formula

C19 H18 N2 O4 S

 Storage (From the date of receipt)
CAS No. 146062-49-9 Download SDF Storage of Stock Solutions

Synonyms CAY10415 Smiles CCC1=CN=C(C=C1)C(=O)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3

Mechanism of Action

Targets/IC50/Ki
mTOT
In vitro
MSDC-0160 reduces resistance in the insulin/IGF-1 signaling pathway and restores IGF-1-induced Akt and GSK-3 phosphorylation. This compound in combination with IGF-1 and 8 mM glucose increases β-cell specific gene expression of insulin, pdx1, nkx6.1, and nkx2.2, and maintains insulin content without altering glucose-stimulated insulin secretion. Furthermore, it promotes human β-cell differentiation and reduces the expression of markers of apoptosis.
In vivo
MSDC-0160 (100 mg/kg p.o.) improves insulin sensitivity by resulting in the large decrease in the product of circulating insulin and glucose in diabetic KKAy mice.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01374438 Completed
Alzheimer''s Disease
Metabolic Solutions Development Company
 July 2011 Phase 2

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