MSDC-0160

Catalog No.S7453 Synonyms: CAY10415

MSDC-0160 Chemical Structure

Molecular Weight(MW): 370.42

MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2.

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Biological Activity

Description MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease. Phase 2.
Targets
mTOT [1]
In vitro

MSDC-0160 reduces resistance in the insulin/IGF-1 signaling pathway and restores IGF-1-induced Akt and GSK-3 phosphorylation. MSDC-0160 in combination with IGF-1 and 8 mM glucose increases β-cell specific gene expression of insulin, pdx1, nkx6.1, and nkx2.2, and maintains insulin content without altering glucose-stimulated insulin secretion. Furthermore, MSDC-0160 promotes human β-cell differentiation and reduces the expression of markers of apoptosis. [1]

In vivo MSDC-0160 (100 mg/kg p.o.) improves insulin sensitivity by resulting in the large decrease in the product of circulating insulin and glucose in diabetic KKAy mice. [2]

Protocol

Animal Research:[2]
+ Expand
  • Animal Models: Diabetic KKAy mice
  • Formulation: Suspended in 1% sodium methyl carboxycellulose/0.01% Tween 20.
  • Dosages: ~100 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 0.01 mg/mL (0.02 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble
In vivo Add solvents individually and in order:

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 370.42
Formula

C19 H18 N2 O4 S

CAS No. 146062-49-9
Storage powder
in solvent
Synonyms CAY10415

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01374438 Completed Alzheimers Disease Metabolic Solutions Development Company July 2011 Phase 2
NCT00760578 Completed Type 2 Diabetes Mellitus Metabolic Solutions Development Company September 2008 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID