Catalog No.S4039 Synonyms: CL 8490
Molecular Weight(MW): 236.27
Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
Purity & Quality Control
Choose Selective Carbonic Anhydrase Inhibitors
|Description||Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.|
|Features||Methazolamide potently inhibits various isoforms of carbonic anhydrase.|
Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.  Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles. 
|In vivo||Methazolamide does not impair respiratory work performance in anesthetized rabbits. |
|In vitro||DMSO||47 mg/mL (198.92 mM)|
|Ethanol||3 mg/mL (12.69 mM)|
|Water||slightly soluble or insoluble|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02758470||Recruiting||Hypoxia||University of British Columbia||November 2016||Phase 4|
|NCT02760121||Completed||Altitude Sickness|Hypertension, Pulmonary||University of British Columbia||May 2016||Phase 4|
|NCT02463357||Recruiting||Mountain Sickness||University of Colorado, Denver|Alma College||August 2015||Phase 4|
|NCT02390284||Recruiting||Glaucoma||University of Miami|National Eye Institute (NEI)||September 2014||Phase 3|
|NCT01702025||Completed||Physiological Function in Low Oxygen Environment||Colorado State University|Defense Advanced Research Projects Agency|University of Colorado, Denver||June 2012||Phase 1|Phase 2|
|NCT01587027||Completed||Mountain Sickness||Poudre Valley Health System|Defense Advanced Research Projects Agency|University of Colorado, Denver||December 2011||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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