Catalog No.S4039 Synonyms: CL 8490
Molecular Weight(MW): 236.27
Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
Purity & Quality Control
Choose Selective Carbonic Anhydrase Inhibitors
|Description||Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.|
|Features||Methazolamide potently inhibits various isoforms of carbonic anhydrase.|
Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.  Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles. 
|In vivo||Methazolamide does not impair respiratory work performance in anesthetized rabbits. |
|In vitro||DMSO||47 mg/mL (198.92 mM)|
|Ethanol||3 mg/mL (12.69 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02758470||Recruiting||Hypoxia||University of British Columbia||November 2016||Phase 4|
|NCT02760121||Completed||Altitude Sickness|Hypertension, Pulmonary||University of British Columbia||May 2016||Phase 4|
|NCT02463357||Recruiting||Mountain Sickness||University of Colorado, Denver|Alma College||August 2015||Phase 4|
|NCT02390284||Recruiting||Glaucoma||University of Miami|National Eye Institute (NEI)||September 2014||Phase 3|
|NCT01702025||Completed||Physiological Function in Low Oxygen Environment||Colorado State University|Defense Advanced Research Projects Agency|University of Colorado, Denver||June 2012||Phase 1|Phase 2|
|NCT01587027||Completed||Mountain Sickness||Poudre Valley Health System|Defense Advanced Research Projects Agency|University of Colorado, Denver||December 2011||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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