Methazolamide

Catalog No.S4039 Synonyms: CL 8490

Methazolamide Chemical Structure

Molecular Weight(MW): 236.27

Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
Features Methazolamide potently inhibits various isoforms of carbonic anhydrase.
Targets
hCAII [1] bCAIV [1] hCAI [1]
14 nM(Ki) 36 nM(Ki) 50 nM(Ki)
In vitro

Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. [1] Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles. [2]

In vivo Methazolamide does not impair respiratory work performance in anesthetized rabbits. [2]

Protocol

Solubility (25°C)

In vitro DMSO 47 mg/mL (198.92 mM)
Ethanol 3 mg/mL (12.69 mM)
Water <1 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 236.27
Formula

C5H8N4O3S2

CAS No. 554-57-4
Storage powder
in solvent
Synonyms CL 8490

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02758470 Not yet recruiting Hypoxia University of British Columbia September 2016 Phase 4
NCT02760121 Recruiting Altitude Sickness|Hypertension, Pulmonary University of British Columbia May 2016 Phase 4
NCT02463357 Recruiting Mountain Sickness University of Colorado, Denver|Alma College August 2015 Phase 4
NCT02390284 Recruiting Glaucoma University of Miami|National Eye Institute (NEI) September 2014 Phase 3
NCT01702025 Completed Physiological Function in Low Oxygen Environment Colorado State University|Defense Advanced Research Projects Agency|University of Colorado, Denver June 2012 Phase 1|Phase 2
NCT01587027 Completed Mountain Sickness Poudre Valley Health System|Defense Advanced Research Projects Agency|University of Colorado, Denver December 2011 Phase 1

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Carbonic Anhydrase Signaling Pathway Map

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