Catalog No.S7280 Synonyms: DU-176b
Molecular Weight(MW): 738.27
Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.
Purity & Quality Control
Choose Selective Factor Xa Inhibitors
|Description||Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.|
In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively. 
|In vivo||Oral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models. |
|In vitro||DMSO||100 mg/mL (135.45 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02952599||Not yet recruiting||Venous Thromboembolism||Daiichi Sankyo Inc.|Quintiles, Inc.|A+ Inc.||March 2017||--|
|NCT02951039||Not yet recruiting||Atrial Fibrillation||Daiichi Sankyo Inc.|Quintiles, Inc.|A+ Inc.||March 2017||--|
|NCT02942576||Not yet recruiting||Atrial Fibrillation||Daiichi Sankyo Europe, GmbH|Daiichi Sankyo Inc.||March 2017||Phase 3|
|NCT02943785||Not yet recruiting||Atrial Fibrillation||Daiichi Sankyo Inc.|Chiltern International Inc.||February 2017||Phase 3|
|NCT02866175||Not yet recruiting||Atrial Fibrillation||Daiichi Sankyo Inc.|European Cardiovascular Research Institute|Kompetenznetz Vorhofflimmern e.V.|Chiltern International Inc.||February 2017||Phase 3|
|NCT02964949||Not yet recruiting||Atrial Fibrillation||Daiichi Sankyo Inc.|Quintiles, Inc.||January 2017||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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